Antivirals for pandemic influenza guidance on developing a distribution and dispensing program by Institute of Medicine (U.S.). Committee on Implementation of Antiviral Medication Strategies for an Influenza Pandemic.

Cover of: Antivirals for pandemic influenza | Institute of Medicine (U.S.). Committee on Implementation of Antiviral Medication Strategies for an Influenza Pandemic.

Published by National Academies Press in Washington, DC .

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  • Influenza -- United States -- Epidemiology.,
  • Influenza -- Vaccination -- United States.,
  • Influenza -- Prevention.,
  • Antiviral agents.,
  • Antiviral agents -- Effectiveness.,
  • Epidemics -- Prevention.

Edition Notes

Book details

StatementCommittee on Implementation of Antiviral Medication Strategies for an Influenza Pandemic, Board on Population Health and Public Health Practice, Institute of Medicine of the National Academies.
ContributionsInstitute of Medicine (U.S.). Board on Population Health and Public Health Practice.
LC ClassificationsRA644.I6 I575 2008
The Physical Object
Paginationx, 122 p. ;
Number of Pages122
ID Numbers
Open LibraryOL17053707M
ISBN 100309118662
ISBN 109780309118668
LC Control Number2008298577

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The committee’s report, entitled Antivirals for Pandemic Influenza: Guidance on Developing a Distribution and Dispensing Program, calls for a national and public process of creating an ethical framework for antiviral use within the context of uncertainty and scarcity. Planning for an influenza pandemic, whether it occurs in the near or distant future, will need to take into account many constantly evolving factors.

The Institute of Medicine (IOM) Committee on Implementation of Antiviral Medication Strategies for an Influenza Pandemic Antivirals for pandemic influenza book asked by the Department of Health and Human Services, (DHHS) to consider best practices and policies for providing.

Antivirals for Pandemic Influenza: Guidance on Developing a Distribution and Dispensing Program Get This Book Buy Paperback | $ Buy Ebook | $ MyNAP members save 10% online. Emergence of a multidrug-resistant pandemic influenza A (H1N1) virus. N Engl J Med ;–2. Nguyen HT, Fry AM, Loveless PA, et al.

Recovery of a multidrug-resistant strain of pandemic influenza A (H1N1) virus carrying a dual HY/IR mutation from a child after prolonged treatment with oseltamivir.

Clin Infect Dis ;–4. We provide a data-driven method for optimizing pharmacy-based distribution of antiviral drugs during an influenza pandemic in terms of overall Antivirals for pandemic influenza book for a target population and apply it to the state of Texas, USA.

We found that during the influenza pandemic, the Texas Department of State Health Services achieved an estimated statewide access of 88% (proportion of population willing to. With the specter of a major influenza pandemic on the horizon, this book is a timely review and update on therapeutics for this sometimes-lethal disease.

Even if today's bird flu does not evolve into a major killer as feared, seasonally epidemic influenza remains a serious disease throughout the world/5(5). Inofficials at the United States Department of Health and Human Services (HHS) developed a Pandemic Influenza Plan to coordinate and improve efforts to prevent, control, and respond to A (H5N1) viruses as well as other novel influenza A viruses of animal (e.g.

from birds or pigs) with pandemic potential. Although it is impossible to. 4 Who Should Get Antivirals and Where. I n this chapter, the committee examines the two main components of plans for antiviral distribution and dispensing: decision making about the groups that will receive antiviral medications for treatment or prophylaxis (consistent with the ultimate goals of pandemic influenza plans) and about the locations.

Antivirals for Pandemic Influenza: Guidance on Developing a Distribution and Dispensing Program [Institute of Medicine, Board on Population Health and Public Health Practice, Committee on Implementation of Antiviral Medication Strategies for an Influenza Pandemic] on *FREE* shipping on qualifying offers.

Planning for an influenza pandemic, whether it occurs in the near or. Antivirals for Pandemic Influenza: A Review of the Clinical Effectiveness × MUPO $ SUPO $ / user X $ Add to cart. Share this book × Copy link Press CTRL-C. Drugs that treat influenza and other viral infections are commonly called antivirals.

There are two classes of such antiviral drugs available to treat the flu: matrix 2 (M2) ion-channel protein inhibitors (such as amantadine and rimantadine) and neuraminidase inhibitors (such as oseltamivir/brand name Tamiflu, or zanamivir/brand name Relenza).

For most of the people who have died from H5N1 influenza, the virus was the cause of death. However, during the pandemic, may people died from pneumonia and other bacterial illnesses. There are also vaccines that protects against infections caused by some types of pneumococcal bacterial, which are a major cause of pneumonia.

Influenza has received much recognition recently as a looming threat that is poised to cause the next pandemic. The devastation created by the Spanish influenza pandemic, which was responsible for at least 40 million deaths, is a recent reminder of the damage that this virus is Cited by: Get this from a library.

Antivirals for pandemic influenza: guidance on developing a distribution and dispensing program. [Institute of Medicine (U.S.). Committee on Implementation of Antiviral Medication Strategies for an Influenza Pandemic.; Institute of Medicine (U.S.). Board on Population Health and Public Health Practice.; United States.

Donnelly CA, Finelli L, Cauchemez S, Olsen SJ, Doshi S, Jackson ML, et al. Serial intervals and the temporal distribution of secondary infections within households of pandemic influenza A(H1N1): implications for influenza control recommendations.

Clin Infect Dis. Jan 1;52 Suppl 1:S– Combating the Threat of Pandemic Influenza: Drug Discovery Approaches consolidates the latest information on diverse approaches into one comprehensive resource.

It is an invaluable, hands-on reference for researchers in medicinal chemistry, pharmaceutical chemistry, drug discovery, biochemistry, virology, microbiology, and public health. The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments.

This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza.

The swine flu pandemic or swine flu was an influenza pandemic that lasted from January to Augustand the second of the two pandemics involving H1N1 influenza virus (the first being the – Spanish flu pandemic), albeit a new strain.

First described in Aprilthe virus appeared to be a new strain of H1N1, which resulted from a previous triple reassortment of bird Specialty: Infectious disease, pulmonology.

An antiviral stockpile is a reserve supply of essential antiviral medications in case of shortage. Many countries have chosen to stockpile antiviral medications against pandemic influenza. [1] Because of the time required to prepare and distribute an influenza vaccine, these stockpiles are the only medical defense against widespread infection for the first six months.

[2]. Pandemic influenza poses a threat to public health at a time when the United Nations' World Health Organization (WHO) has said that infectious diseases are spreading faster than at any time in history. The last major influenza pandemic occurred from to Estimates of deaths worldwide if a similar pandemic were to occur have ranged between 30 million and million people.

Individual. INFLUENZA PANDEMIC Efforts Under Way to Address Constraints on Using Antivirals and Vaccines to Forestall a Pandemic Highlights of GAO, a report to congressional requesters Pandemic influenza poses a threat to public health at a time when the United Nations’ World Health Organization (WHO) has said that infectious diseases are spreading.

Get this from a library. Antivirals for pandemic influenza: a review of the clinical effectiveness. [Canadian Agency for Drugs and Technologies in Health.;]. Antivirals, Influenza Review or older are the least likely to be infected with the pandemic influenza, but those who do get sick Antivirals are not generally recommended if more than 48 hours have elapsed since the last contact with an infectious person.

Although vaccination is the main method to prevent influenza infections in humans, antivirals offer an additional countermeasure against new rapidly-spreading and/or potentially pandemic influenza Author: Adolfo García-Sastre.

seasonal influenza, which importantly may not always be generalisable to a novel pandemic virus, for example a future severe pandemic arising from influenza A(H5N1). However, with hindsight, it has been recognised that the A(H1N1) pandemic virus was of similarFile Size: KB.

Background: The response to the next influenza pandemic will likely include extensive use of antiviral drugs (mainly oseltamivir), combined with other transmission-reducing measures. Animal and in. pandemic preparedness is a community-wide responsibility.

Therefore, it is important to increase the amount of antivirals available in communities for the prevention of pandemic influenza. References 1. The Homeland Security Council. Scenario 3: Biological Disease Outbreak. Optimism about the benefits of antivirals in an influenza pandemic should be tempered by the knowledge that transmissible, pathogenic resistant strains are a.

Article date: October On JWHO declared an official influenza pandemic (phase 6), reflecting global spread of a new strain of human flu H1N1 virus.

Antivirals and resistance: Influenza virus Use authorization during the H1N1 influenza pandemic. Peramivir is highly effective against human influenza A and B isolates as well as emerging Author: Michael Ison. the cdc recommends oseltamivir (tamiflu), peramivir (rapivab), and zanamivir (relenza) for flu.

they are most effective when given within 48 hours after symptoms start to appear. Introduction. Antiviral drugs, especially the neuraminidase inhibitor (NI) oseltamivir, play a major role in plans to mitigate the next influenza pandemic [1,2].Current mathematical modeling studies suggest that antivirals alone are unlikely to significantly reduce the spread and impact of a pandemic, in part due to supply constraints [].However, these studies also predict that antiviral.

Anne C. Stone, Andrew T. Ozga, in Ortner's Identification of Pathological Conditions in Human Skeletal Remains (Third Edition), Influenza. The influenza virus is another pathogen that can be the cause of a pandemic. Flu pandemics occur roughly every 40 years, at times when there is an antigenic shift in the virus.

The first clearly identified flu pandemic occurred inthough earlier. Influenza antivirals will play a critical role in the treatment of outpatients and hospitalised patients in the next pandemic.

In the past decade, a number of new influenza antivirals have been licensed for seasonal influenza, which can now be considered for inclusion into antiviral stockpiles held by the World Health Organization (WHO) and individual by: 2.

A key component of the Australian health management plan for pandemic influenza is the targeted use of stockpiled antivirals to contain infection in early pandemic stages by treating clinical cases, providing post-exposure prophylaxis to close contacts of ill patients, and providing longer term prophylaxis to health care workers caring for ill patients.1 During the pandemic, maintenance of Cited by:   General influenza epidemiology.

It is postulated that 10% of the worldwide population is infected by an influenza virus each year, resulting in a total economic burden of $ billion USD [7, 8].As a testament to the significant toll posed by influenza on public health and healthcare systems, the US Centers for Disease Control and Prevention (CDC) estimated that from toinfluenza Cited by: 3.

Background. The –19 influenza pandemic had an estimated mortality of 40– million deaths worldwide and is considered the worst public health catastrophe of the 20th century. 1 Ninety-one years later in Aprilthe CDC examined two cases of febrile respiratory illness in Southern California that were caused by a novel swine influenza strain (H1N1).

2 The number of Cited by:   Influenza infection is annually responsible for significant morbidity and mortality, particularly among the very young and old.

Recently updated guidelines recommend influenza vaccination of all children aged 6 months to 18 years; however, childhood vaccination remains underutilized. Furthermore, concerns over the reduced efficacy of vaccination in children have further Cited by: Influenza antivirals are also indicated for the prevention of influenza in adults and children (aged 1 year and older for Tamiflu; aged 5 years and older for Relenza) - see product information for further details.

Vaccination is the preferred method of routine prophylaxis against infection with influenza virus. Red Book Online Influenza Resource Page. Influenza Information for Health Care Professionals from the American Academy of Pediatrics —Updated Janu The American Academy of Pediatrics (AAP) Committee on Infectious Diseases has compiled a comprehensive list of influenza resources to serve as a centralized point of reference for vaccine guidance, prevention, treatment, payment.

Influenza A virus resistance to amantadine and rimantadine has developed over the years. During the to influenza season, % of the 18 influenza H3N2 viruses tested in the United States were resistant to adamantanes.

Similarly, % of the pandemic H1N1 viruses tested were resistant to adamantanes. Due to influenza A virus.Antivirals for Influenza. Get concise advice on drug therapy, plus unlimited access to CE.

Pharmacist's Letter includes: 12 issues every year, with brief articles about new meds and hot topics; + CE courses, including the popular CE-in-the-Letter; Quick reference drug comparison charts.A number of journal articles, journal issues, and books and book chapters have been published on the PIP Framework.

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